Romanesco Broccoli in a Beaker

One of the most consistent themes of nutrition science is that vitamin supplements (pills, powders, liquids, etc.) are almost never able to mimic the beneficial effects of foods that contain the same vitamins. Now new evidence suggests that high doses of these antioxidant supplements–but not whole foods containing them–may actually block the beneficial effects of exercise on insulin sensitivity and metabolism.

Exercise has countless benefits for people of all levels of fitness. One of the most important of these is its ability to improve insulin sensitivity and increase metabolism. For this reason, exercise is considered among the most effective ways to protect against type 2 diabetes.

One of the byproducts of exercise, however, is the production of free radicals that results from the breakdown of oxygen in the muscles. These reactive oxygen molecules can damage cells and DNA, and are implicated in many chronic diseases. Since antioxidants can easily neutralize these reactive oxygen molecules, it has been assumed that antioxidants such as vitamins C and E could only benefit the body.

A new study published in the Proceedings of the National Academy of Sciences suggests that rather than help protect against oxidative damage from exercise, high doses of antioxidant supplements may actually hinder the body’s natural protection against oxidative damage and block exercise-induced metabolic benefits.

In the study, human subjects were given either placebo or 500 mg vitamin C twice per day and 400 IU vitamin E. They were then trained in both cardio and strength training workouts at the gym for 5 consecutive weekdays, 4 weeks in a row. This trial was performed on both previously trained and untrained individuals.

Metabolic rates were tested by blood sample both before the trial and after 1 and 4 weeks of training. Muscle biopsies were taken both before and after the trial for all participants. Several measures of metabolism and insulin sensitivity were measured including plasma glucose concentrations, plasma insulin concentrations, maximal oxygen uptake (VO₂ max), as well as several molecular markers in muscle that are linked to insulin sensitivity and are known to promote the body’s natural defense against oxidative damage.

The researchers found that exercise improved measures of insulin sensitivity in all individuals except those given antioxidant supplements. Also, molecules that protect against oxidative damage are upregulated in response to training, but not when antioxidants are administered.

Previous studies suggest that the body’s natural defenses against oxidative damage require activation by a small amount of reactive oxygen chemicals in the body. These same chemicals have been shown to mediate insulin sensitivity in muscles, and in this study both were shown to be blocked by high antioxidant administration.

The researchers suggest that small doses of reactive oxygen molecules such as the amounts produced by exercise are necessary to induce the body’s natural defense against oxidative damage, and that this process is essential for mediating exercise-induced insulin sensitivity. If this is true it could mean that some (but not all) of the metabolic benefits of exercise could be limited by taking high doses of vitamin supplements. This may be particularly important to individuals at high risk for type 2 diabetes.

Interestingly, foods that contain high levels of these antioxidants have previously been shown to be protective against type 2 diabetes. Although the reason for this is still unknown, the authors suggest the benefit is unlikely due to the antioxidant content of the foods and may depend on other factors.

Even if we do not understand the reason vegetables and fruits are the best source of nutrition, we can still enjoy all their benefits. If you choose to continue taking vitamin supplements, it is advisable to stick to a basic multivitamin that does not contain megadoses of one particular nutrient.

Do you take vitamin supplements? Why? How much do you take?
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Go Nuts!

Have you ever noticed that some of your strongest food memories are of rich, fat laden meals shared with family and friends? According to new research, this may not be a coincidence. A study published last week in the Proceedings of the National Academy of Sciences demonstrates that digesting fatty foods enhances memory consolidation using the same neural pathway as emotional learning.

This finding has far reaching implications for cognitive therapies to fight over-eating, but may also suggest new, easy to implement strategies for memory enhancement. Pistachios anyone?

In the study, rats being trained on memory tasks were administered a substance called oleoylethanolamide (OEA) that normally increases in the gut after the ingestion of dietary fat (not carbohydrate or protein). Several days later, the rats given OEA performed better on the tasks than rats that were not, demonstrating enhanced learning.

To determine the neural pathway involved in this effect, the researchers chemically blocked signaling in the region of the brain that receives neural inputs from the gut (solitary nucleus), which abolished the effect of OEA. Next they selectively blocked neural transmission between this region and another region of the brain that has been shown to be critical for emotional learning (amygdala). This also eliminated the memory enhancement effect of OEA, indicating that emotional memory and memory enhancement from fatty food ingestion share the same neural network.

These findings may partially explain the emotional component that is often associated with chronic over-eating, something that frequently involves learned habits triggered by emotional situations.

However, OEA does more than enhance memory. It is also critical in feelings of satiety after a meal (decreasing hunger) and has been implicated in controlling body weight. Is it possible this new information could be harnessed for the power of good?

Low-fat diets have proved to be a colossal failure for both health and weight loss, partially because they encourage over-consumption of starchy (usually refined) carbohydrates. Moreover, vegetable and fish oils are protective against many chronic diseases that plague Western culture. Regularly seeking healthy fats in your diet can help control hunger, promote weight loss and lower risk of disease. But it now seems that healthy fats could also be a useful tool in overcoming emotional eating, a problem more complex than the standard weight gain that comes from 21^st century living.

Another interesting corollary of this study is that fat (specifically oleic acid, a healthy fat found predominantly in olive oil and nuts) may enhance learning and memory. Since the benefits of OEA were only evident when it was administered at the time of or immediately after training, the next time you study or prepare for a presentation you might want to have some nuts around to snack on. Almonds, cashews, hazelnuts, macadamia nuts, peanuts, pecans and pistachios are highest in oleic acid.

Are you interested in foods that could provide cognitive enhancement?